Slow computer help

The past few days my pc has been very slow at opening programs here is a hijack this log...any ideas

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\Explorer.EXE
C:\WINDOWS\system32\LEXBCES.EXE
C:\WINDOWS\system32\LEXPPS.EXE
C:\WINDOWS\system32\spoolsv.exe
C:\PROGRA~1\mcafee.com\vso\mcvsshld.exe
C:\PROGRA~1\mcafee.com\agent\mcagent.exe
c:\progra~1\mcafee.com\vso\mcvsescn.exe
C:\Program Files\QuickTime\qttask.exe
C:\Program Files\Common Files\Real\Update_OB\realsched.exe
C:\Program Files\Zone Labs\ZoneAlarm\zlclient.exe
c:\PROGRA~1\mcafee.com\vso\mcvsrte.exe
C:\WINDOWS\system32\ZoneLabs\vsmon.exe
c:\PROGRA~1\mcafee.com\vso\mcshield.exe
C:\Program Files\Qualcomm\Eudora\Eudora.exe
C:\WINDOWS\System32\wuauclt.exe
C:\WINDOWS\System32\wuauclt.exe
C:\Program Files\Internet Explorer\iexplore.exe
C:\Install\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://red.clientapps.yahoo.com/customize/ycomp/defaults/sb/*http://www.yahoo.com/search/ie.html
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://red.clientapps.yahoo.com/customize/ycomp/defaults/sp/*http://www.yahoo.com
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://my.iwon.com/index.jsp?PG=home&SEC=bnav
R1 - HKCU\Software\Microsoft\Internet Explorer\SearchURL,(Default) = http://red.clientapps.yahoo.com/customize/ycomp/defaults/su/*http://www.yahoo.com
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyServer = localhost:4001
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O2 - BHO: (no name) - {02478D38-C3F9-4efb-9B51-7695ECA05670} - C:\Program Files\Yahoo!\Companion\Installs\cpn\ycomp5_5_7_0.dll
O2 - BHO: (no name) - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 6.0\Reader\ActiveX\AcroIEHelper.dll
O2 - BHO: (no name) - {9527D42F-D666-11D3-B8DD-00600838CD5F} - C:\WINDOWS\System32\IETie.dll
O2 - BHO: (no name) - {AA58ED58-01DD-4d91-8333-CF10577473F7} - c:\program files\google\googletoolbar.dll
O3 - Toolbar: McAfee VirusScan - {BA52B914-B692-46c4-B683-905236F6F655} - c:\progra~1\mcafee.com\vso\mcvsshl.dll
O3 - Toolbar: (no name) - {CA0B9B71-C2AF-11D3-B376-0800460222F0} - (no file)
O3 - Toolbar: Yahoo! Toolbar - {EF99BD32-C1FB-11D2-892F-0090271D4F88} - C:\Program Files\Yahoo!\Companion\Installs\cpn\ycomp5_5_7_0.dll
O3 - Toolbar: &Radio - {8E718888-423F-11D2-876E-00A0C9082467} - C:\WINDOWS\system32\msdxm.ocx
O4 - HKLM\..\Run: [MCUpdateExe] C:\PROGRA~1\mcafee.com\agent\McUpdate.exe
O4 - HKLM\..\Run: [VSOCheckTask] "c:\PROGRA~1\mcafee.com\vso\mcmnhdlr.exe" /checktask
O4 - HKLM\..\Run: [VirusScan Online] "c:\PROGRA~1\mcafee.com\vso\mcvsshld.exe"
O4 - HKLM\..\Run: [MCAgentExe] c:\PROGRA~1\mcafee.com\agent\mcagent.exe
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - HKLM\..\Run: [Zone Labs Client] "C:\Program Files\Zone Labs\ZoneAlarm\zlclient.exe"
O4 - Global Startup: Billminder.lnk = C:\Program Files\Quicken\billmind.exe
O4 - Global Startup: Quicken Scheduled Updates.lnk = C:\Program Files\Quicken\bagent.exe
O4 - Global Startup: Quicken Startup.lnk = C:\Program Files\Quicken\QWDLLS.EXE
O8 - Extra context menu item: &AIM Search - res://C:\Program Files\AIM Toolbar\AIMBar.dll/aimsearch.htm
O8 - Extra context menu item: &Google Search - res://C:\Program Files\Google\googletoolbar.dll/cmsearch.html
O8 - Extra context menu item: Backward &Links - res://C:\Program Files\Google\googletoolbar.dll/cmbacklinks.html
O8 - Extra context menu item: Cac&hed Snapshot of Page - res://C:\Program Files\Google\googletoolbar.dll/cmcache.html
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office10\EXCEL.EXE/3000
O8 - Extra context menu item: Si&milar Pages - res://C:\Program Files\Google\googletoolbar.dll/cmsimilar.html
O8 - Extra context menu item: Translate into English - res://C:\Program Files\Google\googletoolbar.dll/cmtrans.html
O9 - Extra button: AIM (HKLM)
O9 - Extra button: Yahoo! Messenger (HKLM)
O9 - Extra 'Tools' menuitem: Yahoo! Messenger (HKLM)
O16 - DPF: {11260943-421B-11D0-8EAC-0000C07D88CF} (iPIX ActiveX Control) - http://www.ipix.com/download/ipixx.cab
O16 - DPF: {234B7457-1A7E-4268-BA71-9936F0C78BEC} (ContentCleanup3X Control) - http://www.contentwatch.com/cleanup/includes/ContentCleanup3Proj1.cab
O16 - DPF: {2359626E-7524-4F87-B04E-22CD38A0C88C} (ICSScannerLight Class) - http://download.zonelabs.com/bin/free/cm/ICSCM.cab
O16 - DPF: {30528230-99F7-4BB4-88D8-FA1D4F56A2AB} (YInstStarter Class) - http://us.dl1.yimg.com/download.yahoo.com/dl/installs/yinst20040510.cab
O16 - DPF: {33564D57-0000-0010-8000-00AA00389B71} - http://download.microsoft.com/download/F/6/E/F6E491A6-77E1-4E20-9F5F-94901338C922/wmv9VCM.CAB
O16 - DPF: {4ED9DDF0-7479-4BBE-9335-5A1EDB1D8A21} (McAfee.com Operating System Class) - http://download.mcafee.com/molbin/shared/mcinsctl/en-us/4,0,0,83/mcinsctl.cab
O16 - DPF: {70522FA0-4656-11D5-B0E9-0050DAC24E8F} - http://cc.iwon.com/ct/pm3/iwonpm_12_1,0,2,5.cab
O16 - DPF: {BCC0FF27-31D9-4614-A68E-C18E1ADA4389} (DwnldGroupMgr Class) - http://download.mcafee.com/molbin/shared/mcgdmgr/en-us/1,0,0,20/mcgdmgr.cab
O16 - DPF: {CB50428B-657F-47DF-9B32-671F82AA73F7} - http://www.photodex.com/pxplay.cab
O16 - DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) - http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab
O16 - DPF: {EF99BD32-C1FB-11D2-892F-0090271D4F88} (Yahoo! Toolbar) - http://us.dl1.yimg.com/download.companion.yahoo.com/dl/toolbar/yiebiof5_3_16_0.cab