I currently run TrueImage Home 10.0 on my Windows XP machine. I run a differential every day, and a full back up once a week on a schedule. (I think both options are "cloning"... i.e. I've selected "my computer" instead of individual drives and files). I've got a copy of Windows Vista Ultimate on the way, I intend to use the 32 bit version initially. I have read that TI 10.0 is compatible with Windows Vista. However, Windows Vista Ultimate includes BITLOCKER technology, which I also hope to use. This technology encrypts drive information. Is True Image 10.0 also compatible if you use Windows Vista Ultimate bitlocker technology on the drive being backed up?