( Not sure that is the right section: Moderators, is to you ). Windows 64 bit has PatchGuard: I want to know: 1 which security third part softwares doesn't work ( if are ) 2 which security third part softwares work limited because they can't hook the kernel.
I think outpost FW on 64bit windows is more limited in the protection provided by HIPS because of patchguard
Since MSE is the only 64-bit security software out there, then the answer to the question 2 would be all, that are 64-bit compatible only.
As far as I know, MSE is the only one, which takes full advantage of PatchGuard, obviously since MS made both.
There shouldn't be much visible difference from user side as Microsoft offer APIs to supplement what vendors did by kernel hook previously. But internally, all software which depended on kernel hook should be affected including most AVs, HIPS, and sandbox.