I just bought Webroot SecureAnywhere Essentials to go with Sandboxie on my Windows 7 x64 machine. I haven't changed any of the settings and don't really know yet everything that WSA covers. What do you think would be good to run alongside those two programs? Edit: By post #17 below Kees1958 has given detailed instructions on how to set up WSA-E and I'm running WSA-E without Sandboxie. Further Edit: By post #22 Sandboxie is back on, used with WSA-E and Firefox. With Chrome it is just WSA-E. Last Edit: And by post #28 we have some good news from tzuk about Sandboxie, and coming full circle I am happily running WSA-E with Sandboxie and Chrome.