I stopped using AV's for 8 years because they became too bloated and privacy invading. So I relied on HIPS, sandbox, firewall and VirusTotal Uploader. AFAIK, I never became infected with malware. On Win 10 I decided to give Win Defender a try and so far it's working smootly and didn't give me any false positives, so I didn't see any reason to stop using it. You can even disable cloud protection, although this will normally lower malware detection capabilities.