Seems that after updating avast that TF will not load. It just shows "Threatfire - initiating" when hovering over it's tray icon and can't be clicked on, etc. Also sometimes avast is indicating that TFMisc.dll is a trojan "Win32:Rbot-FTK [Trj]". (This is reported to be a false positive by TF forum moderator.) These problems have been reported in both TF and avast forums by several users. If you are having this problem (and believe avast is having a false positive) I have found a way to get TF to load normally although a bit slower than normal. First restore the file if you quarantined it, then go into avast's settings and go to "troubleshooting", select "Delay loading of avast! services after other system services" and reboot. TF should load OK.