I couldn't find information about this error anywhere but I had one last look using different query terms just before I posting my question and voila, there was the answer (in this thread). So, in case anybody else is still looking for the solution to this problem, you need to use the Recovery Media Builder button in Express Mode, rather than the 'Full Scale Launcher'. There seems to be a bug in the system is you use RMB from the full launcher. If you're already in the Full Scale Launcher and want to go back to Express Mode, look for the button on the toolbar. Here is the description of the problem I was having: I am trying to create a bootable USB thumbdrive from Backup & Recovery 14 using the Recovery Media Builder. The progress bar gets about 50% of the way along before I get: "Operation Failed. Error code = 54, error message = Cannot get access to device or open volume." I have tried with two different brand new Sandisk Cruzer 8GB thumb drives, one a Blade and the other a Facet. I have also tried with a 4GB SD Card plugged into a USB reader. I have tried quick and low-level formats of the cards. I have tried formatting them with FAT 32 and exFAT (although I presume this shouldn't matter as the RMB should be formatting them, no?). I have tried to create both Linux and Win PE recovery drives. All of them fail with the same message. I am running Windows 8.1, with Comodo Firewall and Avast Antivirus. I see nothing in the logs for either program or the Windows system logs to indicate any failure outside the Paragon application.