Sandboxie 64 alternative?

Patchgurad does nothing to stop kernel modding. It only causes a BSOD in reaction to the kernel being changed, by performing a routine check.

 

I wonder if the technique in https://www.wilderssecurity.com/showthread.php?t=280128 could be used by Sandboxie 64 bit

 

It won't make sense in the context of Sandboxie. The whole point of using a custom boot loader is to get the driver loaded without a valid digital signature. Sandboxie on the other hand is already signed. So there is no need for dirty tricks.