I too am having the majority of my issues with Vista machines similar to GldRush98's experiences above. What scares me is that Windows 7 is being released shortly and if NOD32 is having issues running on Vista, how is Windows 7 going to look being that they can't get it running error-free on the older Windows versions. Do yourself a favor all, skip the 4.0 series completely and stick with 2.7 until the wheels fall off as I've been advising to others I know who use NOD32. I've seen on the WWW that NOD32 4.0.437 is being touted by some as a "final". If this is their "final" stable build and there is truth to these statements, Eset is in big trouble as this current version is definitely not ready for primetime. It saddens me to have to make comments like these and I really do wish that version 4.0 was 10000% better than 2.7, unfortunately it's not. It shouldn't be too hard to make me a believer Eset, simply make a product as reliable as the 2.7 version and I'll gladly update all my messages related to this here with happy-joy, sugar sweet reviews about just how great NOD32 is.