Currently DefenseWall + Faronics Anti-Executable. Although I do have licenses for others when I feel the urge to change and rearrange.
Trying Faronics AE, but Always use Appguard for its superior protection. In LockDown mode it becomes a default deny policy for all Anti-Excutables.
Embarrassingly enough I've used them all! Just voted AppGuard for current use. I also use poor man's AE - SRP deny policy on SBIE download directories using PGS. Cheers
Since XP is the last Windows OS I'll be using and Vista, 7, 8 compatibility is not an issue, I'll stay with SSM. It's a near perfect match to my needs.
Since my main box will remain XP untill Windows 8 officially releases, like others with this platform, theres almost too many solutions to mention where you just can't go wrong. Malware Defender, EqSysSecure, PowerShadow, etc. Plus a ton of abandonware that seals tight XP systems, in my case, trust-no-exe, FileChangeAlarm, ScriptTrap, etc.
I choose SpyShelter for my normal daily use, but do occasionally try the versions of Voodoo Shield as they are released. I voted SpyShelter as I consider Voodoo Shield for my own use still a bit buggy with not enough features yet (especially to be coming out of beta at any time now).