Running 2 antivirus programs (especially redident protections) at a time is not a good idea and may lead to serious problems like the one you've mentioned.
Have 1 monitoring your system and the other only for scanning your system now and then. As Marcos posted you can have only 1 monitoring your system. NOD32 is IMO the best.
Re: got big problem(not sure if this right place) I ended up with a vundo trojan even with ess running. it couldn't even find it let alone remove it. i had to use a free program ,malwarebytes anti malware to find it and remove all of it. come on eset ,lift your game.
Re: got big problem(not sure if this right place) Beyond the fact that your post is just totally off-topic in this thread, you should submit such stuff to samples@eset.com.