Welcome to the forum! This is not possible for version 2 of NOD32 . In this version one can exclude only in AMON and IMON , not for the on-demand scanning . However , this option is available in the new version 3 which is currently available in Release Candidate State from www.eset.eu/download/beta Do you have a problem with v2 and that is why you want to exclude something from being scanned?