Hi, I have upgraded my Eset Antivirus v 4.2.40 to version 18.104.22.168 on my Windows 2008 R2 x64 fileserver. With version 4.2.40 all was working fine. After installing version 22.214.171.124 all my users are complaining that opening Office document files (xls, doc, etc) from a share on this server is taking very long. Normally opening a document took less than a second and now it can take up to 15 or 20 seconds. I have tested this while disabling the local EAV client (also v 126.96.36.199) on the workstation but that makes no difference. Only when I disable the real-time file protection or add an exclusion for all the shared files or exclude the file extension in the real-time ThreatSense engine then the response on the network is normal again. I have also completely removed EAV and installed it again with the default settings, but that also makes no difference. When I check the statistics within EAV on the server I see that when a client tries to open (for example) a Word document from a share on this fileserver the server is also doing some things with this file. When I tell the server to keep off all is working fine again, but that cannot be the solution of course. Reverting back on the fileserver to version 4.2.40 also solved this delay problem. Does anyone have a clue? Kind regards, Rene.