I've seen plenty on clients' PCs but that doesn't count. From those I'd say McAfee or PC Tools are performance killers, although (as much as I hate to say it) McAfee seems to be improving. I tried a number of them on my netbook earlier this year, with the rationale that any speed issues would be obvious on a slower machine. Ordered subjectively from heaviest to lightest: Comodo Internet Security (took it off very quickly as it slowed things down substantially, no surprise there) Avast free (interacted poorly with MBAM due to known Avast bug, and machine was slow, took it off early) Avira (worked well with MBAM, light, but wanted to replace it) Panda Cloud Antivirus (lighter) F-Secure IS (like not having any antivirus at all) Using Vipre actually sped up my comp- no, not really.
I have only used Norton, Eset NOD32, and Avast, in that order. It's been years since I used Norton V4 AV, and it basically took over. I really shouldn't vote it as the heaviest, because it has probably slimmed down by now, and I haven't seen any hate posts in ages. I find Avast as the best for me to date.
I've only ever used Norton back in 2004/2005 and stopped due to seriously slow-down. Haven't used a suite since.
Mid-2000s Norton has often been mentioned in these forums as the heaviest, but my worst ever experience was with F-Secure AV in 2006. Close seconds in my experience are Kaspersky 2010 and Bit Defender 2008/2009.
I've used Bullguard, Norton & McAfee in the past. McAfee was the most bloaty I think, although Norton was the most problematical. I don't use suites now.
Coranti, G Data, old versions of Norton and F-Secure... Although I don't use AVs in real-time protection, I like to try them whenever a major version is released...
Since the question asked "you ever used", it was Kaspersky in 2003. My sickly little computer barely moved. Went to Dr. Web and it acted young again. And although it was an AT, I must mention TDS-3. I got so excited reading about it, I installed a trial, but my computer would freeze while the voice was saying whatever it said. Boy was I depressed.
Used GData and BitDefender last 2009 for a shor while and it made my system crawl. Tried FSecure IS also a bit lighter than the two but system wasstill slow. Went back to Avast/Avira.
I would have to say Kaspersky after the .325 version 7 update and the 2009 version. I have tested Bitdefender versions that were worse but the poll did say "you ever used" and I did not actually "use" Bitdefender for more than the 5 minutes it took to discover it was unusable. Also Norton 2004 was pretty bad but I did not use it longer than the trial period.