probably-- the isr service would still be running, but you couldn't interact with it without the program interface (what you're wanting to manually run). but i doubt there's any harm in what you want to do- give it a try and let us know
Just in case it was port activity that prompted your question WWS. You can turn it off https://www.wilderssecurity.com/showthread.php?p=1173912&highlight=port#post1173912
Taking FDISR off the start up list didn't make any change in the start up speed so I put it back the way it was. I was eliminating things to try to find out why I was having hangups at the Windows logo screen resulting in long startups or forced reboots. I found out that by removing Sandboxie from the list, my startups haven't misbehaved since...now constantly around 40 seconds with no hangups. Thanks, guys.
sandboxie was slowing you down? thats peculiar- its usually very light and trouble-free, is it not? its probably more that it's conflicting with some other security software, which could be fixed by configuring the compatibilities within sandboxie's menu. upgrading to latest version couldnt hurt as well