http://www.osnews.com/story/22872/Linux_Not_Fully_Prepared_for_4096-Byte_Sector_Hard_Drives Was what had me thinking. rrrh1(arch1)
IIRC parted allows you to set things up properly, if you know what you're doing. So I would think any distro would work, provided you partitioned the drive with e.g. Parted Magic.
Looks like WD had it right then... Linux is not impacted when set up properly !! That's good news !! rrrh1 (arch1)
The distro isn't really going to matter since all distros use the same kernel. The kernel is where all the hardware stuff is done (that's the definition of a kernel). So, as long as the distro in question is using a recent enough kernel, it will work.