I have 2 different Vista 64 boxes, one is a Ultimate and one is a Home Premium. I clean installed Vista on both boxes, setup all the devices and made sure everything was running well and then installed NOD32. Everything seemed fine for a time then box 1 started having a problem with opening web pages in Firefox and 32bit IE. 64bit IE worked fine and I could ping and do nslookups from the command prompt just fine. I was pretty baffled by this problem and found no help in any forums I frequent. I ended up formatting the box and starting over and it has been running fine ever since. A little later I read a post somewhere of someone else with NOD32 having the same problem and tucked that away in the back of my head. I had never even considered that NOD32 could have been the problem. Fast forward to now and box 2 started having the same problem. 32bit IE and Firefox could not pull up pages but 64bit IE could. Remembering what happened before I uninstalled NOD32 and everything started working fine. Also on this PC I had been having performance problems with Supreme Commander. I attributed this to this PC being a little older than the other but after uninstalling NOD32 due to the other problem the game now runs great with NOD32 gone. I have been using NOD32 for years in XP and have never had a performance issue with it. Now I run into this and am not sure what to think. I do know my box runs like it should when I get rid of NOD32. Both boxes are Athlon 64 boxes. One is a 3000+ with 2GB of RAM and SATA drives and the other is a A64 X2 4800+ with 4GB of RAM and SATA drives. With what happened with Surpreme Commander I am beginning to wonder if NOD32 is causing some sort of major performance degradation with Vista 64 and I just don't notice it as much on the X2 box. So that is my story. I don't really know what to do other than to uninstall NOD32. I am not willing to live with these problems just to have NOD32 installed. Does anyone have any ideas or know of this issue with NOD32 and Vista 64?