Since I'm troubleshooting some problems with FirstDefense-ISR on my new Vista PC, I'm operating with two primary FD-ISR snapshots: one with NOD32/Windows firewall, the other with KIS v7. For the last two days, when I reboot into the NOD32 snapshot, a Vista system tray icon gives me a message saying a program was blocked from startup. The program is Comodo BOClean v4.25 which I have to give permission to activate. Until recently, BOClean started up with no issues. The only change to my PC in the last two days has been the automatic installation of some Windows Vista "reliability" updates (Microsoft's notions of "reliability" and "compatibility" doin't coincide with my own). I read on a Microsoft discussion forum that some folks had experienced problems with a recent update blocking various programs. I can't figure out any method to stop Vista from blocking BOClean. I've uninstalled and reinstalled BOClean (clicking "Run as Administrator") several times to no avail. What I can't fathom is that Vista in my KIS snapshot isn't blocking BOClean from starting even though it contains the same Windows updates. Also, every time I install BOClean v4.25 then reboot, there's no BOClean system tray icon and I get a message saying the BOC425.XVU file containing the database can't be found and I need to run the updater (which doesn't fix the problem). When I track this file down, it's always in one of three locations: the BOClean program file folder, my C drive folder, or a user application folder. There's no consistency as to where BOClean initially places this file. I can't go into the configuration menu to establish a location for the database because until this file is placed where BOClean wants it (and that location varies from installation to installation), there's no icon or way to access the BOClean menu. What I wind up doing is copying the BOC425.XVU file to two locations: the C drive folder and the BOClean program file folder. Then when I reboot the BOClean system tray icon appears, the program functions, and I'm able to access the configuration menu. Then I'm able to set a specific location for the BOC425.XVU file and delete the extra file(s). Why this is happening is a total mystery to me. I hope some of the resident computer wizards have some cogent advice (other than buying a Windows XP installation CD).