I currently own licenses for KAV6, KIS6, Outpost 4, and BOClean, so please don't factor cost into any comments left for my question. Currently I have KAV6 as my realtime AV and Outpost 4 with blockpost and the Antispyware plugin running real time. My concern is that the Outpost spyware protection might not be up to par with something free specifically designed to protect against spyware, such as Spyware Terminator. Also, I've seen KIS6 Antihacker and Comodo stacking up pretty well lately in comparisons to Outpost. My question is, out of the followup configurations, which would you choose, and why? I'm open to modifying my setup based on suggestions, so please state some good reasons for your decision. The only thing I'm set on keeping static is KAV (whether it's part of KIS or not) as my primary virus scanner. We have good history Here are the following setup's I'm considering: KAV6 + Outpost4 w/ blockpost and AntiSpyware plugins (current) KAV6 + Comodo + Spyware Terminator KAV6 + Outpost4 + Spyware Terminator KIS6 + Spyware Terminator Also, I run BOClean, MVPS host file, some immunization tools, IE lockdowns, some light hardening tools, Opera, the usual necessities... so please keep on topic regarding my real time protection. Thanks everyone, looking forward to some good responses!