I have 2008 R2 domain, with redirected profile folders to file server. Latest Endpoint makes Office 2010 apps unusable, applications are crashing randomly, all issues are going away when I downgrade to 4.2 Business. Now File Server 4.5 edition makes Windows Deployment Services unusable, adding drivers to boot images effectively crashes entire server. I would say any operation that involves mounting images, boot, capture or install causes a hang. Issues went away after downgrading to 4.2 again. Both File Server 4.5 and Business 4.2 are interfering with Veeam Backup & Replication when running Hyper-V replication. It's causing Hyper-V XML config files corruption, causing replicas to disappear from destination host. Removing Eset products from destination host resolves the issue. I've worked on this with Veeam and Microsoft, both confirmed it's Eset issue. Veeam had another customer with Eset and identical issue, removing Eset antivirus solved the issue. I've filed performance issues tickets before, it resulted in discovery of locks in Eset filters and eventually a newer version, but all the issues are still remaining. It's so severe in my case I have no other option but to downgrade. I will upload report from Splunk tomorrow with all the logs with crashes from the last few months while using Endpoint Antivirus.