Rollback RX (for personal use) still seems like the best security setup. If the system and the applications + data are divided on separate harddrives, it doesn't seem to cause any problem that only the system is protected by Rollback RX while the rest relies on standard Windows security. Not that a virus wouldn't be able to delete stuff on application + data drives, but many years of experience tells that, if you don't particularly look for such virus then the only thing you'll get are accidental program bugs and advertisement(hacks) crashing or slowing the CPU. So Sandboxie really isn't necessary, since those problems can be removed by a rollback. Also Sandboxie causes several problems with for example installation of larger files and its sandbox is a double of data, so it needs constant maintenance about what to delete and what to overwrite originals. Instead it is much easier in Windows to relocate user folders on the system drive to the application drives, so they're excepted from Rollback layering. And those User folders that can't be relocated - like AppData - which some applications also use for data storage, they can particularly be excepted in Rollback RX advance settings. 99.9% very simple and easy security on PC.