Is there particular anti virus that secureanywhere will play nice with or secureanywhere alone better..?
WSA does work best on it's own but some users like to have another AV or AM and WSA is designed to work with most other AV's & AM's but is it necessary that up to you. Also note that if do become infected using WSA one of Webroot's malware experts will help you clean your system or remotely connect to your system and clean it themselves. Also WSA monitors unknown processes and if determined bad it with rollback to the pre-infection state. HTH, TH