I was recently pointed at https://www.wilderssecurity.com/showthread.php?t=37509 by Fred Langa's newsletter (you all get this ... right www.langa.com there is a free version but I pay for the plus version and it is an excellent read). This provides a comprehensive set up and tweak list for NOD32 version 2.5 and is excellent. The only problem I had (and this is the warning) is that after applying all the tweaks GetRight download manager stopped getting file sizes for new downloads and really struggled to complete downloads. Be aware that the HTTP compatability settings need to be set with care (half way down page 2): and in particular all the GetRight settings need to be set for compatability mode. The problem arises becase when "Higher efficiency" is set all files are downloaded first by NOD32 and scanned before being passed to the application that requested them. Sometimes this means that applications make the request and it is then downloaded twice! Once for NOD32 to check and once for the application, but in GetRights case it tries to download it and sticks in the last few bites forever and so the download never completes!