Well, after botching up an install of NOD32 on Vista Beta 2, I looked a bit into the forums as to why I was getting 100% CPU usage and no network response. Turns out IMON was interfering with the TCP/IP stack, and so the previous solution was to disable IMON. However IMON is a pretty integral part of NOD32, so I decided to try a slightly less black/white approach. I re-installed NOD32 with IMON disabled, and then after rebooting, entered NOD32 setup, clicked on IMON and went into IMON Setup. I clicked on Setup under Compatibility setup on the bottom of the POP3 tab, and moved the slider to the middle. Initial testing shows that the one change is sufficient to allow NOD32 to work without nuking the Vista TCP/IP stack. Any further insights or tweaks to ensure smooth usage with minimal loss of functionality?