We currently use one the consistently top-ranking antivirus vendors across our site (Avira). It works well (to the best of our knowledge) but the central management is not great when you have hundreds of machines, and it's ultimately still "traditional" antivirus in that it's primarily pattern based but with a "cloud" component to do lookups on unknown executables. I'm starting to look at what else is out there and that horrid phrase "Next Generation" is the best way I can describe it, essentially they seem to focus on preventing malware and exploits by looking at behaviour. Names that I've heard of are those such as: Cylance Palo Alto TRAPS MalwareBytes Anti-Exploit Who else should be on the list? Respectfully, please keep in mind that with several hundred endpoints central management and reporting has to be there so please don't recommend anything that is entirely standalone and aimed at domestic use as however good it may be, it won't be an option.