Making a Snapshot ,my system freezes

When making a Snapshot of my System do I have to shutdown Anti virus software and other programs that access the hard drive that is being copied?
I seem to have the problem of the my PC freezing when using Firstdefense
with everything running from the System tray.I can't use the mouse or do anything at all.My System is a Quad Core with 4GB of Ram running with Vista Home Premium.
I have the programs below running from the system tray.
NOD32
Threatfire
Look 'n'Stop
Smart Defrag
BOClean
Thank you

 

Thanks for your quick reply.What about NOD32,BOClean and Threatfire with there Real time protection.

 

I never disable Nod or Boclean and have never had any problems. Don't use ThreatFire. The only thing that I disable at all is Anti-Executable. I don't have a defragger that defrags in real time but that is one thing that I would disable if I had it. Good luck.

Acadia

 

Thanks for your help.I got a Snapshot with Threatfire disabled like you suggested.I just carried on working on the computer as I normally would and it worked fine.I then started Threatfire up again and did a copy of the Snapshot which worked OK but I didn't start any more programs whilst it was being copied.So it looks as if it's OK with Threatfire providing i'm not doing anything with my PC.
Thanks again for your help,much appreciated.