We may never know. Reflect performed flawlessly before I patched it and has been performing properly since I restarted after the patch, so if there was interference, I'd be surprised if it could be limited only to the post-update, pre-restart state of Reflect. What's especially weird to me is that the Reflect application itself did still launch, since it displayed the popup dialog giving me the option to postpone the scheduled backup job. It's just that it didn't actually perform the backup job afterward. My guess is that one of Macrium's own background processes or the Macrium Service didn't start up properly after the patch.