Interpreting messages in Spyware blaster

I have recently installed the above software and I see that if it doesn't like a particular change in a given category, one is faced with a choice of "Approve Change" or "Deny Change". without some further knowledge it is difficult to decide which course to take, as interpretation of the Old and New data statements is unclear. Is it right to assume that every change is undesirable and therefore to deny the change? This seems unlikely but some input from more experienced users woul be useful. I futher note that this prompt is coming from Spybot Search & Destroy, rather than Spyware Blaster. Of course I do have the Spybot installed also. Advice please?