*SOLVED* High RPC Latency on Exchange 2010 with Mail Security We recently installed Mail Security on a new Server 2008 R2 x64 Exchange 2010 box running all roles with about 150 mailboxes. This server is a virtual server in an ESX 4.0u1 environment hosted by three Dell R710's with dual quad 5620 cpu's and 48GB of RAM each. Current resource allocation is two cpu's and 12GB RAM. Storage is provided by an EqualLogic PS6000 SAN. There is a 4Gb link to both the SAN (iSCSI) and LAN. LAN connectivity is provided by an HP 5412zl switch. When installed and configured per ESET's recommended settings, we experienced high RPC latency to the server. Normal latency is in the 5-20ms range and our latencies jumped to around 300ms. This was not a big deal for users with small mailboxes, but for those with large (5-6GB) mailboxes is made them pretty much unusable. I have attached the configuration XML for review if it can be of assistance in finding out where we went wrong (Rename to .XML). For now we have had to uninstall the product and rely on our Barracuda appliance for protection. Any and all input is welcome - thanks!