The message comes from Vista and it advises you there may be issues with some of the software installed on your PC. For example I've seen this on some PCs with older versions of Adobe Reader installed but that have no noticeable problem. It's essentially MS saying "We see you have program X installed, however there may be some issues. If you have an issue, click here and we'll list the issues we know about and the fixes we have for those issues." If you click on it you should get a list of Vista / NOD32 related issues and fixes. Have you ever installed (and even then uninstalled) anything from Eset or McAfee on the PC? Even the Online Scanners? Check through the Internet Explorer Add-Ons (Tools, Internet Options, Programs, Manage AddOns) and see if any are listed as from a publisher such as ESET. Try disabling them, restart IE and see if the problem stops. Finally submit a SysInspector log to ESET as per the request above.