I have been using True Image successfully for years, and recently bought an external Maxtor USB drive. It did not come formatted and I used the Maxtor CD to set up the drive. But it also installed the Maxtor One Touch backup program, which seems to prevent True Image from working. True Image would try to start the backup, and hang there for a few minutes until it gave Error 70021 - Cannot Access Drive. I uninstalled the TWO Maxtor items in the Add / Remove Programs part of the Control Panel, and now True Image works again ! So for anyone who buys a Maxtor One Touch, be sure to uninstall their backup software: you don't need it with True Image !