I recently built a new budget rig running Win7 HP x64. I had everything installed, updated and running fine. I then installed the latest Comodo a few days again. I'm using Firewall and Defense+ only. I have everything allowed and trusted that I want allowed and trusted. No more popups. The problem happens when I first start my computer. Everything loads very quickly to the desktop but then when I try to open a program, usually Firefox or Thunderbird, nothing happens for about 3 minutes. Finally it will load and the system works fine. When I check the D+ Unrecognized files, there is always an entry for the latest definition updates for Avast. Sometimes I can start up or reboot the PC and this behavior does not occur. On those occasions there is no entry for the Avast definitions. I keep adding them to the safe list but each update is a different file so that doesn't really cut it. Does anyone know how to get Comodo to play nice with Avast? I was running the same combo on my old XP computer with no such issues. Thanks.