Cannot save in excel-BIG problem

Hello all,
I use excel heavily for business purposes. I use Win7 home edition(64bit) with office 2007 (and now 2010)
The problem appears randomly (not always) whenever i try to save a file. I get:
Your changes could not be saved to ******.xls because of a sharing violation. Try saving to a different file


When i disable "Antivirus and antispyware protection" from the icon i am ok.

I have also tried to disable ESET's firewalland use Windows instead, still the same problem.
I use the latest version. I hope ill find a solution soon, otherwise i will have to change AV program.

Thank you

 

are you trying to save on network drive? If you disable document protection does it work better?

see (in step 3 disable integrate into system under Document protection)
http://kb.eset.com/esetkb/index?page=content&id=SOLN2132

 

Thank you for the reply.
No i dont save it in a network drive. It is just my local drive.