Im running NOD32 AV 3.0.650. With the way its working now, I need to have Real-Time Filesystem protectoin off in order to even use my computer. My computer has 4 gigs of ram, and a Core 2 Duo T7500, running Vista x64 Ultimate. It seems something to do with the Real-Time scanning when its one slowing down the computer immensely. I see a LOT of memory faults in my monitor for ekrn.exe and the CPU is either at a constant 100% or if i leave it on overnight or so, it goes to spiking to 100% every 5 seconds, and keeping my computer at 50% cpu usage, while with it off, my cpu usage is like 10-20%. Ive googled and searched, and I can not find a fix for it. Ive tried turning off Advanced Heuristics and didn't help any. Any help would be greatly appreciated. P.S. Im running this same version on a desktop running XP 32bit sp2 and it runs like a dream. SO i believe it might be something with vista.