"Every now and then, it varies." I change my security very little since I've been using NOD32, it runs awesome on my laptop, now the only things i've added in the last few months are EXE Radar Pro and Voodooshield since they are awesome and the developers are top notch! I don't see much changing in my config anytime soon My other programs I use have been the same for years other than portable apps.
Security setup? It depends, when I'm on the mood I could change my setup like 10 times in a week. When I'm lazy I might won't change a single thing for the whole year. So I voted for the second choice.