Playing UDP packets on different NICs

Is it possible to playback and receive UDP packets on different NICs (network interface cards) that were used to transmit and receive the original packets?
I tried to use Colasoft Packet Player with no success.
Explanation: I try to capture packets sent from computer A to computer B on my LAN. I want this file to be played on a different LAN (i.e. computer A' tansmits the packets to computer B').
I beleive that it does not work because the MAC addresses of the computers are not identical.

 

Actually it works.

MAC address is just used for identification.
In fact a NIC can encapsulate the frames/packets with any MAC address.
A burned in MAC address is merely an allocated ID rather than a fixed number you have to hold it through your entire life.

Main idea: the MAC address in the packets is irrelated to the burnned in MAC addree of your NIC.

Examples:
1) ARP poisoning.
2) virtual machine in briging network mode. The virtual use the same physical NIC of the "real" machine, but appears as different MAC <-> IP pairs.

You can simply change your MAC address in the NIC config tab.

Conclusion: Physical MAC address difference will not affect the packet player from playing packets with any MAC address.