Access to Keyboard

I have tried searching the forums for this topic, but failed to find anything.
Perhaps being a new member, I was not expert enough.
QUESTION
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I am using Windows XP Home and have IE7, Comodo Pro, Spywareblaster, Spyware Terminator, AVG, Spybot.

I get requests from some of these for "keyboard access". Even IE comes in with IEXPLORE.EXE, EXPLORER.EXE, EXPLORE.EXE. All of these I tend to BLOCK.
I do an AV and spyware/malware check each day - nothing, I seem clean.

As the above are all legitimate systems and are totally responsible for my security - am I correct ? Should I let them all have access permanently by checking the "allow" and "remember this" on the various alerts and security classifications ?

Any helpers ?