McAfee VirusScan Enterprise with Windows XP and IE6 in organization I work for as well with more than 5000 systems.
I almost always see McAfee on Laptops of visiting representatives from other companies. The only exceptions that I remember are Norton and ESET NOD32, only one instance each.
I work in a company that employs probably close to 600-700 PC's. They are very big into TrendMicro and believe wholeheartedly in it.
From this poll, it seems like McAfee VirusScan Enterprise is widely used in workplace environments. It's no wonder then why exploit tool targets McAfee ePO. Exploit Tool Targets Vulnerabilities in McAfee ePolicy Orchestrator (ePO)
One company I work for uses Symantec End Point. No idea why either. I have showed them countless times how easily you can bypass it.