For close to 2 years now, I've been running Shadow Defender in Sandboxie (or is it the other way around?) with no problems. A question though. What happens to the automatic signature updates that were installed into my antivirus and anti-malware programs while in a Shadow Mode/Sandboxie mode after rebooting? Edit: observed updates coming in while in Shadow Mode, recorded their numbers, rebooted and sure enough, they were gone. So, that means updating manually before enabling SD.