From The Windows 8.1 Kernel Patch Protection: From Microsoft Windows 8.1 Kernel Patch Protection Analysis & Attack Vectors: From Malicious Utility Can Defeat Windows PatchGuard:
Interesting stuff. Seems like it isn't that easy to disable PatchGuard, but the KPP-Destroyer tool is still a bit worrying. Like I said in some other thread, I think it's best to implement PatchGuard as a hypervisor.