Firefox buttons not working consistently?

I've never had this happen before, but just recently, I'm noticing that certain buttons in my firefox don't work unless I click them rapidly at least ten times. This includes anything on my tab bar other than the actual tabs, like the New Tab button, the Flashblock button, the Close Other Tabs button, the Greasemonkey button, and the Refresh button. It also happens with the address bar and the downloads dialog buttons (open, save as).

I'll click on them and they won't work, and I'll need to rapidly spam the mouse button ten to fifteen times before they'll actually work. I considered this might be an issue with my mouse hardware, but the mouse works fine on all other things I use it for. It's only on these firefox buttons that it doesn't work on consistently.

Any ideas?

 

If that were happening to me I would make note of my preferences, export my bookmarks, uninstall including deleting my Firefox profile, and then reinstall it.