There should be no problems; http://www.f-prot.com/products/home_use/dos/ Take a look at a recent thread here at Wilders; http://www.wilderssecurity.com/showthread.php?t=14858 And here is an excellent, detailed article about the program; http://www.geocities.com/uzipaz/eng/f-prot.html Overall F-Prot for DOS is an excellent choice as a backup scanner to your main AV.
Take a look at these threads where they give details about scripts which can be used to automate the updating procedure; http://www.wilderssecurity.com/showthread.php?t=15635;start=msg97316#msg97316 http://www.wilderssecurity.com/showthread.php?t=10735;start=msg93448#msg93448 http://www.geocities.com/uzipaz/eng/f-prot.html http://www.claymania.com/F-pup.exe
F-Prot for dos has no resident protection but F-Prot for Windows does and will work nicely on just about any machine.