Safe mode

[Sandex]

Can NOD32 scan PC in safe mode?

[Capp]

Yes it can.

in fact, its recommended to do so if you have a piece of malware on your system it just can't get rid of.

[Bubba]

Originally Posted by Sandex

Can NOD32 scan PC in safe mode?

Yes, more info in program Help section indexed as scanning in safe mode

Safe mode
If the graphical interface of ESET NOD32 Antivirus is launched in safe mode, a dialog window reporting that the application is to be run in safe mode is displayed. Since in safe mode the operation of all programs is limited, it is not possible to open the graphical interface of ESET NOD32 Antivirus as in the standard mode.
The displayed window will let you run a computer scan. If you wish to check your computer for malicious code, select the option Yes.
Doing so will launch scanning in a separate window using the same parameters as the default computer scan profile after the installation of ESET NOD32 Antivirus.
Select the option No to close the dialog window; ESET NOD32 Antivirus will perform no action.

[trjam]

To me, no software should ever have to be put into safe mode to remove malware. That is just a plain deficiency in the software's capabilities.