I had one false positive with Comodo AV on my system, EAM and MSE had the same one. For everyday use by average user it does as good as anything.Now if your going to throw stuff at it trying to destroy it ,you probably can just like any one of them but the average user is never going to find that crap. With DefenseWall and Comodo AV I'm covered and my seven and five year old boys can play their kid game sites and never hear a word out of them except for some fighting.
The only reason I'm not using it now is I don't need Defense+ and the sandbox with DefenseWall and I hate having it there shut off. If you don't want it to be pretty good then you better not try it.