[Joeythedude]

Laptop with Windows 7 Ultimate

Physical :
2 Hard drives , OS/Games Drive , Backup Drive.
ATA Hard drive password on OS/Games Drive

Always On:
OS & Microsoft Tools : Win FW , Win Defender , EMET
Configuration changes: OpenDNS , Downloads Folder , "Run" Folder

Occasionally Use:
MS Applocker , Sandboxie , Virustotal, Secunia PSI

Backup/Recovery.
Acronis 2011 - Backups from OS/Games Drive to Backup Drive.
Acronis 2011 - 1 Image of 0S/Games on external Drive ( Not tested )

Paid
Windows Ultimate , Acronis 2010 , Sandboxie , and an IronKey for storage / internet cafes.

Settings
Admin/User : Run as Admin with UAC (High)
EMET : Applications set - Browers & Flash & Steam
Downloads folder : No execution allowed.
"Run" folder : Full execution allowed , has Path Access in Applocker
Applocker : Have 2 simple script files on desktop to switch Applocker On and Off.
Sandboxie : only used to block untrusted USB's.
VirusTotal : have "send to" VirusTotal on right-click menu.
MS Office : is uninstalled.
Acronis 2011 :
1) Backup User Profile and Games Installations to Backup Drive
2) Backup Settings ; Password , Differential , Daily / At Logon ( varies) , Max Backup size set


The "Run" Folder lets me run any new program, at any time. For me this gives a good balance between convenience and security.